This easy to use test kit is sent to your home. The kit contains everything needed for collecting specimens, including shipping materials and pre-paid postage for sending specimens to the lab. Results are emailed 7-10 days after lab receives specimens. A hard copy is also sent by mail. No lab visit required.
The Intestinal Permeability Assessment analyzes urine for the clearance of two non-metabolized sugars, lactulose and mannitol. Identifies "leaky gut" and malabsorption.
This test includes Lactulose / Mannitol drink. *THIS TEST MAY NOT BE SUITIBLE FOR THOSE ALLERGIC TO LACTOSE OR WHO MAY BE LACTOSE INTOLERANT
Increased permeability of the small intestine can:
• Increase the number of foreign compounds entering the bloodstream.
• Allow bacterial antigens capable of cross-reacting with host tissue to enter the
bloodstream, leadingto auto-immuneprocesses.
• Enhance the uptake of toxic compounds that can overwhelm the hepatic detoxification
system and lead to an overly sensitized immune system.
Increased gut permeability has been observed in a range of disorders such as:
• Inflammatory Bowel Disease (IBD)
• Inflammatory jointdisease
• Chronicdermatologic conditions
Studies have demonstrated that the increased permeability observed in patients with
ankylosing spondylitis, rheumatoid arthritis, and vasculitis maybe an important factor in the
pathogenesis of these disorders.
Decreased permeability, on the other hand,appears as a fundamental cause of malabsorption,
subsequent malnutrition, and failure to thrive. In certain disease states of thesmall intestine, such
as gluten-sensitive enteropathy, permeability to large molecules may increase while permeability
to small molecules decreases, a result of damage to the microvilli. As a result, nutrients become
even less available to assist in the detoxification of antigens flooding the system.
Possible causes of intestinal permeability include:
• Intestinal infection
• Ingestion of allergenic foods or toxic chemicals
• Deficient secretory IgA
• Trauma and endotoxemia
The Intestinal Permeability Assessment directly measures the ability of two non-metabolized
sugar molecules to permeate the intestinal mucosa.
The patient drinks a premeasured amount of lactulose and mannitol. The degree of intestinal
permeability or malabsorption is reflected in the levels of the two sugars recoveredin a urine
sample collected over the next 6 hours